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"Emergency medicine" 7 (70) 2015

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Correction of Cerebrovascular Diseases in Patients with Myocardial Infarction

Authors: Khizhniak A.A., Stroienko K.S., Nikonov V.V., Movchan M.H.
Kharkiv National Medical University, Kharkiv
Kharkiv Medical Academy of Postgraduate Education, Kharkiv
Kharkiv Clinical Emergency and Immediate Care Hospital named after prof. О.I. Meshchaninov, Kharkiv, Ukraine

Categories: Medicine of emergency

Sections: Clinical researches

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У статті розглядаються питання удосконалення діагностики й оптимізації лікувальної тактики при церебральній недостатності у хворих з гострим інфарктом міокарда.

В статье рассматриваются вопросы усовершенствования диагностики и оптимизации лечебной тактики при церебральной недостаточности у больных с острым инфарктом миокарда.

The article deals with the issues of improving the diagnosis and optimizing the therapeutic approach in cerebral insufficiency in patients with acute myocardial infarction.


гострий інфаркт міокарда, цереброваскулярна патологія, когнітивні розлади, антигіпоксанти.

острый инфаркт миокарда, цереброваскулярная патология, когнитивные нарушения, антигипоксанты.

acute myocardial infarction, cerebrovascular pathology, cognitive disorders, antihypoxants.


Coronary artery disease (CAD) is the most widespread pathology in Ukraine. Myocardial infarction (MI) is one the most serious complications resulting from СAD. Annually about 50 thousand cases of MI are recorded in Ukraine, where percentage of employable population reaches 29.0%. One of the causes of unfavorable course of acute MI is vascular disorder of the brain. According to the data provided by different authors, frequency of such disorders varies from 30 to 80%. Prognosis concerning cerebrovascular morbidity is unnerving: up to 2020 it will increase by 75%.   
In most cases cerebrovascular pathology is a spectrum of pathological conditions which includes impairment of mental functions of different severity degree from mild cognitive disorders to dementia. Revealed interaction between cardiac and cerebral dysfunction in patients who had acute disorders of cerebral circulation has resulted in introduction of such term as cardiac encephalopathy that stresses timeliness of the study of cerebral disorders in patients with acute and chronic cardiac pathology. 
The standards of diagnosis and treatment of cardiovascular diseases and MI have been accepted in Ukraine. But in order to reveal cerebrovascular insufficiency, additional methods of examination such as defining of C-reactive protein, cortisol are required. According to the data of different studies, cortisol reflects individual level of stress, severity of the disease as well as it can be associated with development of mental stress. Besides, it is used as a predictive marker in cerebral ischemia, myocardial infarction and as a survival index of patients. C-reactive protein is a predictive marker in acute coronary syndrome as well as a marker of mortality in MI connected with depression and uneasiness.  
Nowadays, the best methods of diagnosis of cognitive disorders are neuropsychological tests: scale of assessment of mental status MMSE, MoCа scale, Beck’s scale, clock drawing test, ten words memorization test. 
In spite of the available standards in treatment of СAD there is still no uniform approach for medically induced correction of cerebrovascular disorders in acute myocardial infarction. But there are some investigations dedicated to use of antihypoxants (containing succinic acid) for correction of cerebrovascular disorders in acute myocardial infarction. As agents of quercetin have become widely used for treatment of acute myocardial infarctions as well as for correction of cerebrovascular disorders, then study of application of these medications taken as a whole remains interesting for use in current treatment of patients.


Improvement of diagnosis and optimization of treatment policy of cerebral insufficiency in patients in acute period of myocardial infarction. To define the level of cerebral insufficiency depending on degree of myocardial infarction injury. To reveal disorders of mental status at early stage in patients with acute myocardial infarction using neuropsychological tests. To estimate the role of cortisol in cardiocerebral syndrome. To estimate the role of C-reactive protein in cardiocerebral syndrome. To elaborate methods of medically induced correction of cerebral pathology by means of antihypoxants together with quercetin depending on degree of myocardium injury.

Materials and methods 

The study involved 40 patients according to the following enrollment criteria: patients with acute MI aged from 35 to 60 with disturbance of mental status. Discontinuation criteria will be the following ones: burdened neurological history. Depending on therapy type the patients have been divided into three groups: group 1 – patients taking quercetin and antihypoxants; group 2 – patients with acute MI without antihypoxants; control group – patients without MI. 
The study methods include:
1. Assessment of the patient’s condition and verification of diagnosis (complete blood count, clinical urine analysis, blood sugar, quantitative troponin, total cholesterol, LDL, HDL, triglycerides, atherogenic index, total protein, bilirubin, urea, creatinine, ALT, AST, prothrombine index, ultrasonography of the heart.
2. Estimation of course and prognosis of the disease (assessment of cortisol level).
3. Estimation of course and prognosis of the disease (assessment of C-reactive protein).
4. Estimation of cognitive disorders (neuropsychological tests – MMSE, clock drawing test, ten words memorization test). 


Cerebrovascular insufficiency aggravates the course of acute myocardial infarction. Untimely diagnosis of cerebrovascular disorders and absence of adequate treatment result in their further progressing. Unfortunately, at the early stage and often in the process of development, cognitive disorders may remain undetected if physicians do not carry out history taking and screening neuropsychological study properly. Therefore, all patients with cardiovascular diseases and acute myocardial infarction, including those who are not old, should be appropriately examined as for possible cerebral disorders. The methods of proper correction of cerebrovascular insufficiency should be elaborated. As use of quercetin along with antihypoxants has not been studied enough, this issue claims particular attention for further timely correction of cerebrovascular diseases in acute myocardial infarction.


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